Pre-test preparation or requirements
• Sample can be drawn at any time. No fasting or special preparation required.
• Blood sample should taken in two vials: EDTA and plain vials.
Tests included in package
CBC- Complete blood count
TIBC- Total iron binding capacity
UIBC- Unsaturated iron binding capacity
Significance of package
Screening, diagnosis, monitoring, severity and prognosis of Anemia. It helps in categorization of type of anemia and its treatment. Helps in evaluating the status of iron in body and its capacity to absorb iron.
Iron found in blood is mainly present in the hemoglobin of the RBC's. Its role in the body is mainly in the transportation of oxygen and cellular oxidation. Iron is absorbed in the small intestine, and bound to a globulin in the plasma, called transferrin and transported to the bone marrow for the formation of hemoglobin. Increased serum levels are found in hemolytic anemias, hepatitis, lead and iron poisoning. Decreased serum levels are found in anemias caused by iron deficiency due to insufficient intake or absorption of iron, chronic blood loss, late pregnancy and cancer. Increase in TIBC is found in Iron deficient anemias and pregnancy. Decrease in TIBC is found in hypoproteinemia, hemolytic/ pemicious/ sickle cell anemias, inflammatory diseases and cirrhosis.
The Serum ferritin level is small in healthy adults, generally in the range of 10-350 ng/mL, and its concentration due to age and gender change. The availability of sensitive methods for measuring serum ferritin have significantly advanced the ability to detect iron deficiency and overload. The ferritin levels will surge in 1-month-old baby, then decrease in the second and third month, after 6 month, the concentration will lead to a very low level and maintain this level throughout childhood, then increase again during the puberty, especially boys. The age has a significantly positively relationship with serum ferritin level in women, while in men there is no such relationship. Recent literature suggests that ferritin provides a more sensitive, specific and reliable measurement for determining iron deficiency at an early stage. In chronic inflammatory disorders, infections, neoplastic disease and in chronic renal failure, there is a disproportionate increase in serum ferritin levels in relation to iron stores, but there is no specificity. In addition to elevated in liver cancer, pancreatic cancer, lung cancer, the ferritin level will not increase in other gastrointestinal tumors such as esophageal cancer, gastric cancer and colorectal cancer. Studies have shown that in patients with liver cancer, serum feritin decrease indicate a effective treatment, increases indicate malignant cancer or recurrence, sustained increases indicate the poor prognosis, it is the determination of serum ferritin as one of the efficacy detection, especially for the patients with negative alpha-fetoprotein.