ALANINE AMINOTRANSFERASE- ALT/ SGPT
Pre-test preparation or requirements
• Sample can be drawn at any time. No fasting or special preparation required.
• Sample should taken in plain vial.
Male: 5- 40 U/l
Female: 5- 31 U/l
Significance of test
Alanine aminotransferase (ALT) is the most widely used biomarker of liver injury. ALT is involved in the transamination of alanine, and it is present in the liver at much higher concentrations than in other organs. Leakage of ALT from the hepatocyte into the blood occurs following hepatocellular injury. Although elevations in ALT can be highly suggestive of liver injury, ALT is not liver specific and extrahepatic sources of circulating ALT includes skeletal or cardiac muscle damage and drugs that increase ALT gene expression (e.g. fenofibrate)
Alanine aminotransferase was formerly known as serum glutamate pyruvate transaminase (SGPT). The ALT enzyme is found in liver, kidney, skeletal muscle, and myocardium. ALT is elevated in serum under conditions of significant cellular necrosis and is used as a measure of liver injury. ALT concentration may be increased in hepatitis, myopathy, congestive heart failure, liver or biliary duct damage.