Pre-test preparation or requirements
• Sample can be drawn at any time. No fasting or special preparation required.
• Sample should taken in plain vial.
28- 100 U/l
Significance of test
In acute pancreatitis, amylase in the blood increases (often to 4-6 times higher than the highest reference value, sometimes called upper limit of normal).
The increase occurs within 12 hours of injury to the pancreas and generally remains elevated until the cause is successfully treated. Then the amylase values will return to normal in a few days.
In chronic pancreatitis, amylase levels initially will be moderately elevated but often decrease over time with progressive pancreatic damage.
Amylase levels may also be significantly increased in patients with pancreatic duct obstruction, cancer of the pancreas, and gallbladder attacks.
Decreased blood and urine amylase levels may indicate permanent damage to the amylase-producing cells in the pancreas.
Increased blood amylase levels with normal to low urine amylase levels may indicate decreased kidney function or the presence of a macroamylase, a benign complex of amylase and other proteins that accumulates in the blood.
Since reference values for amylase vary from laboratory to laboratory, depending on the test method used, there is no universally accepted number that can be called normal or high.
In acute pancreatitis, elevated amylase levels usually parallel lipase concentrations, although lipase levels may take a bit longer to rise than blood amylase levels and will remain elevated longer.
Chronic pancreatitis is often associated with alcoholism. It may also be caused by trauma, pancreatic duct obstruction, and seen in association with genetic abnormalities such as cystic fibrosis.
Amylase levels may be moderately elevated with chronic pancreatitis but often decrease over time with progressive pancreas damage.